Thread: sertraline a selective serotonin uptake inhibiter fat loss

The antidepressant sertraline a selective serotonin uptake inhibitor, has been reported to promote weight loss

sertraline may have beneficial effects on body composition and carbohydrate metabolism The mechanisms by which sertraline might influence body composition, carbohydrate metabolism, and adiponectin regulation are not known. We hypothesize that sertraline may affect body composition and carbohydrate metabolism by blocking serotonin reuptake and thereby increasing signaling at the central serotonin receptors, specifically 5-HT2C, which appear to regulate food intake, body weight insulin sensitivity, and glucose homeostasis

Weight gain is a common complaint of patients receiving antidepressant drug treatment. The antidepressant sertraline, a selective serotonin uptake inhibitor, has been reported to promote weight loss. In this study, measurement of urinary concentrations of 3-methoxy-4-hydroxyphenylglycol (MHPG) was used to help classify the response of patients who were depressed and overweight to treatment with sertraline. The authors found a significant difference between the average weight loss of 1.06 lb/week in patients with a low urinary MHPG and the average weight loss of 0.42 lb/week in those with a high urinary MHPG. During this study, the maximum weight loss by a patient was 69 pounds over 36 weeks.

DOSAGE FOR FAT LOSS CARBOHYDRATE METABOLISM INSULIN SENSITIVITY
50mg