In rats given 10% of the diet as calcium-D-glucarate, serum estrogen has been noted to be reduced 23% relative to control.
http://www.ncbi.nlm.nih.gov/pubmed/3091283

Calcium-D-Glucarate is thought to confer protection against breast cancer, at least in part via the reduction of estrogen levels but mostly due to augmenting the excretion of pro-carcinogenic drugs that are subject to glucuronidation.
http://www.ncbi.nlm.nih.gov/pubmed/7744577