DarrenW29
02-04-2023, 05:03 PM
ARBS
improve insulin sensitivity
work like ai lowering aldosterone
Candesartan treatment attenuated the sodium-retaining action of hyperinsulinaemia. These findings suggest that inhi- bition of angiotensin II action by candesartan can improve insulin sensitivity and inhibit the sodium- retaining action associated with hyperinsulinaemia in essential hypertension.
Glucose and insulin concentrations
The fasting insulin levels in the HF group were significantly higher compared with those in the NC group (P<0.05; Table I). However, animals receiving candesartan cilexetil displayed significant reductions in insulin levels (36%; P<0.05) compared with those in the HF group.
Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II.
Telmisartan seemed to be more effective at suppressing aldosterone
Telmisartan improves insulin sensitivity in hypertensive patients with insulin resistance or T2DM. Telmisartan treatment of hypertensive patients with T2DM not only improved blood pressure, glucose and lipid metabolism, but also improved endothelial function for the prevention of atherosclerosis.
At the end of study when compared to standard the percent reduction of blood glucose level in Telmisartan group was 51.95%. While in standard it was 60.42%. The reduction in mean percent blood glucose level was statistically significant (p<0.001) compared to diabetic control group.
DOSGAE
Candesartan 8-16mg
telmisartan 40-80mg
improve insulin sensitivity
work like ai lowering aldosterone
Candesartan treatment attenuated the sodium-retaining action of hyperinsulinaemia. These findings suggest that inhi- bition of angiotensin II action by candesartan can improve insulin sensitivity and inhibit the sodium- retaining action associated with hyperinsulinaemia in essential hypertension.
Glucose and insulin concentrations
The fasting insulin levels in the HF group were significantly higher compared with those in the NC group (P<0.05; Table I). However, animals receiving candesartan cilexetil displayed significant reductions in insulin levels (36%; P<0.05) compared with those in the HF group.
Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II.
Telmisartan seemed to be more effective at suppressing aldosterone
Telmisartan improves insulin sensitivity in hypertensive patients with insulin resistance or T2DM. Telmisartan treatment of hypertensive patients with T2DM not only improved blood pressure, glucose and lipid metabolism, but also improved endothelial function for the prevention of atherosclerosis.
At the end of study when compared to standard the percent reduction of blood glucose level in Telmisartan group was 51.95%. While in standard it was 60.42%. The reduction in mean percent blood glucose level was statistically significant (p<0.001) compared to diabetic control group.
DOSGAE
Candesartan 8-16mg
telmisartan 40-80mg