aas heal injury’s

[DarrenW29]

A widely reported side effect of AAS use is an increased risk of tendon rupture.68,69 Two hypotheses are often described in the literature: (1) AASs have no direct effect on tendons but can induce muscular hypertrophy and increased muscle strength, without associated tendon strengthening, resulting in an increased risk for rupture, or (2) that AASs, in combination with physical exertion, have a deleterious effect on tendon structure and healing.28,69 Preclinical studies in rodents have suggested that AAS use may negatively affect collagen synthesis and matrix metalloproteinase activity, which are both involved in tendon repair and homeostasis.70,71 However, as a recent review noted, investigations to date have produced inconsistent results, and it is still unclear how AASs influence tendons
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it’s unclear how was affect tendons something worth adding but not saying they do not


AASs have shown great promise as potential therapeutic tool in a variety of clinical scenarios relevant to orthopaedic surgeons. Based on current evidence, AASs can augment biological healing after muscle injury, fracture repair, or rotator cuff repair and have the potential to improve postoperative recovery after ACL reconstruction or total joint arthroplasty. To realize the clinical potential of AASs in orthopaedic surgery, substantial efforts are needed in the preclinical and clinical arenas to better characterize their effects on tissues and establish optimized regimens.