DarrenW29
02-27-2023, 12:56 PM
For decades, testosterone has been the sole instrument in the andrologist’s arsenal for the ongoing treatment and management of male hypogonadism. However, with increased interest and emerging research, there now exist more options than ever to help combat the sequelae of this devastating clinical condition. Nandrolone is a particularly compelling medication that has significant beneficial effects on joint pain in hypogonadal men, reducing their reliance on chronic pain medication and reducing pain scores in responding men by more than half. Although further studies are required to replicate and characterize these findings on a larger scale, they suggest a novel indication for a fascinating drug that appears to hold great promise for future clinical use. It is increasingly apparent that the field of modern andrology is evolving rapidly with ever-expanding options to assist our patients in novel and exciting ways.
Results
Forty-eight eligible patients completed the initial survey, and 18 men (37.5%) responded to follow-up requests. The median duration of therapy was 62 [interquartile range (IQR), 48–73] days, and the median dose of ND was 110 (IQR, 100–150) mg. Participants’ mean age was 46 [standard deviation (SD), 11] years old with a racial makeup consisting of 15 Caucasian, 2 Hispanic, and 1 African American.
Of the 18 men who responded to their follow-up request, 13 (72.2%) reported marked improvements in joint pain, with 5 (27.8%) reporting a decreased need for longstanding pain medication. Amongst responding patients, pain scores were reduced on average by 52%. Even when accounting for treatment non-responders, the collective improvement in pain scores observed across each of the 4 sub-categories of the RAPS was both statistically significant and profound (Figure 2). No adverse events were noted.
Results
Forty-eight eligible patients completed the initial survey, and 18 men (37.5%) responded to follow-up requests. The median duration of therapy was 62 [interquartile range (IQR), 48–73] days, and the median dose of ND was 110 (IQR, 100–150) mg. Participants’ mean age was 46 [standard deviation (SD), 11] years old with a racial makeup consisting of 15 Caucasian, 2 Hispanic, and 1 African American.
Of the 18 men who responded to their follow-up request, 13 (72.2%) reported marked improvements in joint pain, with 5 (27.8%) reporting a decreased need for longstanding pain medication. Amongst responding patients, pain scores were reduced on average by 52%. Even when accounting for treatment non-responders, the collective improvement in pain scores observed across each of the 4 sub-categories of the RAPS was both statistically significant and profound (Figure 2). No adverse events were noted.