Reta versus tirzepatide for contest prep, GI sides made the decision for me

[Jock]

Two preps on tirzepatide and the bloating close to the show was killing me both times. Switched to retatrutide this time and the GI profile is night and day. No gut distension, appetite control is there without the nausea. Starting dose was 0.25mg twice weekly, working dose ended up around 1mg split Monday and Thursday. Anyone else made this switch? Curious what dose people are landing at.

[FrankfurtFit]

Made the same switch six months ago and have not gone back. The GI profile with retatrutide is noticeably cleaner. I run 0.5mg Monday, 0.5mg Thursday for maintenance during a prep phase. The triple receptor mechanism gives better fat oxidation than tirzepatide - the glucagon component does real work on lipolysis. My working advice: start at 0.25mg twice weekly and escalate every two weeks based on appetite response. Moving too fast on dose escalation is where most people get GI problems.

[FLbodybuilder]

The pharmacology of the switch makes sense. Tirzepatide hits GLP-1 and GIP. Retatrutide adds glucagon receptor agonism which drives thermogenesis and fat oxidation through a completely different pathway. The GI bloat issue with tirzepatide is well-documented and relates to gastric emptying delay - reta appears to have a milder effect on gastric motility at equivalent fat loss doses. For prep use specifically the cleaner GI profile makes a real practical difference when you're already cutting food intake aggressively. I use 1mg twice weekly in the final 10 weeks.

[CaliBro]

West coast comp guys are almost all on reta now. The tirzepatide bloat issue is a real thing and it kept biting people close to shows. Reta at 0.5-1mg twice weekly is where most people land for prep use. The appetite suppression on day 5-6 of the weekly cycle is when you know you need to either increase frequency or bump dose slightly.

[Paris GH]

Switched to retatrutide from tirzepatide four months ago. The GI experience is markedly better. In France sourcing is complicated but the quality difference justifies the extra effort. I run 0.5mg twice weekly during prep phases alongside a therapeutic GH dose. The clean appetite suppression without bloating or gut distension makes a real difference to training quality in the final weeks before a show.