The effect of the anabolic steroid oxandrolone on the healing rate of a standardized full thickness linear wound on the back of the rat was studied. Oxandrolone was given orally by gavage in peanut oil at a dose of 0.1 mg/kg/day. A placebo powder in peanut oil was given at the same dose to a control group. Parameters monitored were time to complete wound closure, wound hydroxyproline content and tensile strength, as well as histology. We found that wounds closed completely in 12+/-3 days with oxandrolone, compared to 18+/-3 days for a placebo, a statistically significant difference. The rate of body weight gain was identical in both groups. Hydroxyproline content of the healed incision site was 23+/-4 mg/g tissue vs. 17+/-3 mg/g tissue, while the tensile strength increased to 185+/-13 g/mm2 vs. 102+/-18 g/mm2 in the oxandrolone and placebo groups, respectively. Both parameters were significantly increased with the anabolic steroid. Histologic examination showed a wound that contained more mature and densely packed collagen and was also hypercellular with oxandrolone treatment. We conclude that the anabolic steroid oxandrolone significantly enhanced wound healing unrelated to any generalized increase in protein mass as would be reflected in body weight.
The effect of the anabolic steroid oxandrolone on the healing rate of a standardized full thickness linear wound on the back of the rat was studied. Oxandrolone was given orally by gavage in peanut oil at a dose of 0.1 mg/kg/day. A placebo powder in peanut oil was given at the same dose to a control group. Parameters monitored were time to complete wound closure, wound hydroxyproline content and tensile strength, as well as histology. We found that wounds closed completely in 12+/-3 days with oxandrolone, compared to 18+/-3 days for a placebo, a statistically significant difference. The rate of body weight gain was identical in both groups. Hydroxyproline content of the healed incision site was 23+/-4 mg/g tissue vs. 17+/-3 mg/g tissue, while the tensile strength increased to 185+/-13 g/mm2 vs. 102+/-18 g/mm2 in the oxandrolone and placebo groups, respectively. Both parameters were significantly increased with the anabolic steroid. Histologic examination showed a wound that contained more mature and densely packed collagen and was also hypercellular with oxandrolone treatment. We conclude that the anabolic steroid oxandrolone significantly enhanced wound healing unrelated to any generalized increase in protein mass as would be reflected in body weight.
Exogenous corticosteroid administration is known to impair wound healing. Patients with severe burns or wounds who require corticosteroids for management of an underlying disease have an increased rate of catabolism and decreased rate of healing. Anabolic steroids have been reported to restore anabolism and wound healing. Our objective was to determine if the oral anabolic steroid oxandrolone could increase the rate of wound healing by decreasing the rate of catabolism in corticosteroid-dependent patients with burns and partial-thickness wounds. Twenty-two corticosteroid-dependent patients with major burns (12) or skin slough disorders (10) were studied. All burn patients required a skin graft, and reepithelialization of the donor site was used as a marker of healing. The skin slough disorders were all partial thickness, and reepithelialization of the wounds was the marker for healing. The burns and skin slough disorders were divided into a standard care group and standard care plus oxandrolone (20mg/day) group. The disorders requiring corticosteroids were collagen vascular disease (12), organ transplant (4), and asthma, or other respiratory diseases (6). Twenty patients survived. The two deaths were in patients with progressive graft versus host disease. No complications relative to the control of the underlying disease were noted with use of the anabolic steroid. We found that the time to healing of skin donor sites in the standard care group was 20 ± 4 days compared to 13 ± 3 days in the oxandrolone-treatment burn group, a significant difference (p < 0.05). We found that the time to reepithelialization in the skin slough disorders with standard care was 25 ± 6 days compared to 17 ± 4 days with the addition of oxandrolone, also a significant difference (p < 0.05). Weight loss was 50-percent less with the addition of oxandrolone compared to standard care, also a significant difference (p < 0.05). We can conclude that providing an anabolic steroid to a corticosteroid-dependent burn or wound patient eliminates the impaired wound healing.
ANAVAR TO HEAL QUICK
DOSAGE 20-50mg
