
Originally Posted by
Cr25ovet2
when you take an oral steroid such as winstrol, undergoes a first-pass metabolism in the both the intestines as well as Liver. Some drugs can be absorbed more or less totally intact, after only moderate metabolic activity, while some are absorbed only after very extensive metabolic activity. Once it is through this first pass, a given drug then circulates in the blood until it is acquired by another tissue, such as skeletal muscle. Now, if the drug reaches the Liver again, it may undergo what is cleverly known as “second-pass” metabolism. Of course, in the case of winstrol, an injectable version is available, and when we compare the oral and injectable versions of winstrol and their effects in your body, I think there’s some surprising differences. The injectable is (naturally) put right into your bloodstream and only undergoes the far less extensive second pass metabolism, while the oral must endure the gut and Liver on it’s first pass before ending up in circulation.
Now, here’s the interesting part: When you inject winstrol, instead of taking it orally, you actually get more nitrogen retention (4) (and hence we can infer, more new muscle tissue is being built). SO if you are trying to use winstrol to build new muscle tissue, the injectable version is going to be far superior to the Oral version.