Tirzepatide vs retatrutide for a 12 week cut, who has actually run both back to back?

Lining up a 12 week cut and I keep going back and forth between tirz and reta. Never run either so I am coming at this blind. From what I can gather tirz is the dual agonist everyone started on and reta is the newer triple that adds the glucagon receptor on top, but I do not really get what that actually means day to day on a cut. Has anyone here run both back to back and felt a real difference, or is it mostly the same appetite kill with a different price tag? Trying to work out if reta is worth chasing down or if I just start on tirz since it is easier to get hold of.

Ran tirz first cut then reta the next and the difference for me was the muscle hold. On tirz at 1mg I was flat and dropping strength along with the fat, reta at the same dose I kept the lifts and the scale still moved. Tirz killed my appetite harder in week one, reta was more I just stopped thinking about food rather than feeling sick. Both want a slow ramp from 0.25 or you get the acid reflux waking you up at night.

Ran tirz for one cut then reta the next and the biggest difference for me was the gut feel. Tirz killed my hunger completely but left me bloated and a bit flat, on reta I just ate less without thinking about it and none of that distended gut that sema and tirz give you. The thing nobody mentions enough, reta held my strength in the deficit way better, the glucagon side seems to keep the muscle building drive going where tirz had me feeling weak and depleted by week 6. Only real warning is do not rush the titration, start 0.25 a week and build over a month, the guys who jump to 2 or 3mg early end up at 3am with heartburn and feeling sick and blame the compound when it was the dose.

Worth flagging for anyone new to either of these, ramp it slow. Quarter mg a week for the first 2 to 3 weeks then step up, the guys who jump straight to 1mg plus end up with acid reflux waking them at night. Reta tends to be the kinder one on the gut once you are titrated up properly.

Reta is the stronger of the two for fat loss, no question, but it punishes you if you rush the dose. Start low and build it up slow. Theres no prize for jumping straight to the top.

Whichever one you land on, ramp it properly or youll have a rough time. 0.25mg a week for the first 2 or 3 weeks, then 0.5, then 0.75, then 1mg. Guys who skip the ramp and jump straight in at 1 to 2mg get the heartburn and acid reflux waking them up at night, thats true for both compounds. The bloated distended gut feeling everyone hates on sema is mostly absent on reta at a sensible titration, which is a big part of why the prep crowd has drifted to it over the last year.

Ran both back to back, tirz cut last winter then reta this spring at the same 1mg. Honest difference for me was the gut, tirz had me bloated and gassy for weeks while reta was almost nothing once I got past the first couple of jabs. Scale dropped about the same on both but I held more strength on reta, whether thats the glucagon receptor doing something for lean tissue or just me eating a bit more protein I cant say for sure. Either way ramp slow, 0.25 for the first few weeks, the lads who jump straight to 1mg get the heartburn waking them up at night.

The titration point is the one most people skip. Both compounds punish you for going too fast. I started tirz at 1mg week one and the heartburn waking me up at 3am was brutal for 2 weeks. Rebuilt slowly from 0.25mg and it was a completely different experience. The compound was not the problem, the ramp was.

Ran tirz for one cut and reta for the next, back to back. Biggest difference for me was tirz absolutely kills hunger in week one, zero interest in food, where reta you just naturally eat less and less often without consciously restricting. Scale moved about the same on both but i held more strength and fullness on the reta, that glucagon component really does seem to spare muscle in a deficit. Whatever you pick titrate slow, 0.25 a week for the first few weeks then climb, the guys who jump straight to 1 to 2mg get the heartburn and reflux waking them at night.

Solid breakdown in here. Only thing id stress for anyone new to either compound, respect the titration. Start at 0.25 and ramp slow. The guys getting the acid reflux and night heartburn are almost always the ones who jumped straight to 1mg plus. Patience on the ramp saves you the worst of the sides.