Metformin myostatin

Metformin, another AMPK activator, also stimulated myostatin expression at low concentrations. In addition, ectopic expression of AMPK wild-type α subunit (enhancing AMPK activity) and AMPK K45R mutant (knockdown AMPK activity) enhanced and reduced myostatin expression, respectively. These results indicate that AMPK stimulates myostatin expression in C2C12 cells, providing an explanation for the negative effect of AMPK on muscle growth.

Metformin enhanced myostatin mRNA expression…

Even if Metformin as a little bit of power to block Myostatin , i believe dont worth using something that makes you lose weigh , hunger , indigestion and bad felling all day. The only think Metformin make sense is to help improve insulin sensitivity but you have berberine much better much less sides but mostly for people with eating disorders and obese people . Never see the logical on metformin to fitness athletes