PSA jumped from 3.1 to 3.8 in a year on TRT - rate of change or absolute number, which one actually matters?

3.8 at 47 on TRT is not a crisis but it is a number you need to track consistently from here. What matters most is the year-on-year trajectory. If it was 2.4 eighteen months ago and is now 3.8 you have a 1.4 rise in 18 months which is close to the 0.75 annual velocity threshold that most urologists flag. If it was 3.4 last year and is now 3.8 that's a much slower climb and far less concerning. Get the history, calculate the rate, decide from there.

Just got my quarterly bloods back and PSA crept up to 3.8. Been on TRT for 3 years, 47 years old, running 200mg/week. Last year it was 3.1 so that's 0.7 in 12 months which is getting close to the 0.75 annual velocity threshold I keep seeing mentioned. Currently stacking mast with test which I know doesn't help the PSA picture but wasn't expecting this kind of jump. Anyone actually had to see a urologist over numbers in this range or is 3.8 at 47 still within expectation on cycle?

Rate of change is what actually matters, not the raw number. If you were at 2.8 six months ago and now you're at 3.8, that 1.0 jump in six months is the part worth taking seriously. But if you've been hovering around 3.6-3.8 for the last couple of years and it's stable, 3.8 at 47 on TRT is not alarming on its own. One thing worth checking - if you're running any Masteron or Proviron alongside your TRT, those will push PSA up more than test alone because of the DHT activity. Worth dropping them out for 6 weeks and re-testing before you decide anything.

Rate of change is the key thing the guys above have nailed - a single reading in isolation does not tell you much. If you are tracking it year on year and it is stable that is very different from a fast climb over 12 months. Get a baseline off cycle if you can and go from there.

rate of change is the number that matters, not the single reading. seen guys panic at 4.0 when their velocity is flat year on year, and others who should have seen a urologist at 3.2 because it doubled in 8 months. track it annually at minimum if you're on long-term TRT.

If mast or proviron has been in the mix at all, those DHT compounds push PSA harder than test alone - direct prostate stimulation, not estrogen-related. Worth flagging what you were actually running when that 3.8 came back, not just the TRT dose. Helps you track whether it's the protocol change or just normal variation when you pull the next set of labs.

the number that matters isn't the 3.8 itself, it's what it was 12 months ago. PSA velocity above 0.75 per year is the actual red flag - a steady creep from 2.4 to 3.8 over 3 years on TRT is a very different story to jumping from 2.8 to 3.8 in 12 months. if you're running mast or proviron on top of test those DHT compounds will push it higher than test alone, worth flagging that when you get the follow-up done. annual tracking from here is just standard practice.