Anyone tried the DIY TRIIM protocol? HGH + retatrutide + DHEA for actual age reversal

The skepticism about the epigenetic clock data is fair given the sample size but the DIY variations people are running here are interesting to follow. Keep the bloodwork coming if anyone is tracking IGF-1 or other markers alongside.

The injection fatigue argument is the one I keep coming back to. If you're already running test, GH, and reta - adding HGH pulses from CJC/Ipa on top of that is another 2-3 subq shots a day. At some point the protocol becomes its own full-time job. I backed off the GHRP stack specifically because of that. Running the retatrutide instead of metformin makes more practical sense for most people who are already pinning for bodybuilding reasons.

The epigenetic clock skepticism is fair but I think people miss the point arguing about whether GrimAge predicts lifespan to the year. The interesting part is the thymus regeneration data - actual measurable T-cell production improvement in a 9-person study. That's not placebo territory. Running 3 IU pre-bed, 50mg DHEA daily, and 1mg reta twice a week. 14 weeks in. Sleep has been noticeably better from about week 6. Bloodwork at week 16 to see what IGF-1 is doing.

The injection fatigue point is real and it's the thing that kills most of these longevity stacks before anyone gets useful data. GH twice a day, reta twice a week, BPC near an injury site, maybe slin peri-workout - you're looking at 15 plus pins a week before adding anything else. At some point the compliance falls apart not because the compounds stop working but because people get sick of pinning.

The ones who stick with it long-term tend to consolidate wherever possible. Reta twice weekly is fine. GH once daily AM instead of split. BPC only when there's an active injury, not year-round. Trim the protocol to what's sustainable and you actually get the data.

The epigenetic clock skepticism is valid but the TRIIM study got replicated with larger cohorts since then. 9 participants made it easy to dismiss at the time. The DIY versions are where the real-world data is building now - not waiting for a pharma-sponsored trial that is never coming.